Ranked by metric tons in 2010
| Rank | Ch. | City/Country | Code | MT | ’10/’09 | |
| 1 | same | Bogota, Colombia | BOG | 526,844 | 17.0 | % |
| 2 | same | São Paulo, Brazil | GRU | 430,850 | 12.6 | % |
| 3 | same | Mexico City, Mexico | MEX | 397,142 | 22.0 | % |
| 4 | same | Santiago, Chile | SCL | 285,427 | 11.6 | % |
| 5 | same | Lima, Peru | LIM | 271,794 | 17.0 | % |
| 6 | same | Campinas, Brazil | VCP | 255,008 | 38.0 | % |
| 7 | same | Buenos Aires, Argentina | EZE | 212,890 | 30.8 | % |
| 8 | same | Quito, Ecuador | UIO | 169,571 | 19.2 | % |
| 9 | same | Manaus, Brazil | MAO | 157,156 | 10.2 | % |
| 10 | +1 | Guadalajara, Mexico | GDL | 130,785 | 32.4 | % |
| 11 | -1 | Rio de Janeiro, Brazil | GIG | 108,382 | -2.2 | % |
| 12 | +1 | Medellin, Colombia | MDE | 105,265 | 17.8 | % |
| 13 | +1 | Panama City, Panama | PTY | 98,922 | 17.9 | % |
| 14 | -2 | Caracas, Venezuela | CCS | 85,655 | 39.6 | % |
| 15 | same | San Jose, Costa Rica | SJO | 80,723 | 11.7 | % |
| 16 | — | Santo Domingo, Dom. Rep. | SDQ | 60,454 | 22.3 | % |
| 17 | -1 | Guayaquil, Ecuador | GYE | 59,142 | 7.0 | % |
| 18 | +2 | Managua, Nicaragua | MGA | 57,573 | 36.7 | % |
| 19 | -1 | Salvador, Brazil | SSA | 48,770 | 8.9 | % |
| 20 | +2 | Monterrey, Mexico | MTY | 48,710 | 42.4 | % |
| 21 | same | Fortaleza, Brazil | FOR | 48,336 | 24.2 | % |
| 22 | -3 | Recife, Brazil | REC | 38,018 | -15.1 | % |
| 23 | same | Cali, Colombia | CLO | 34,382 | 4.0 | % |
| 24 | -7 | Brasilia, Brazil | BSB | 32,651 | -35.2 | % |
| 25 | +3 | Montevideo, Uruguay | MVD | 27,395 | 13.2 | % |
| 26 | +1 | Barranquilla, Colombia | BAQ | 27,380 | 2.6 | % |
| 27 | -3 | Porto Alegre, Brazil | POA | 26,969 | -11.3 | % |
| 28 | +2 | San Luis Potosi, Mexico | SLP | 26,754 | 11.6 | % |
| 29 | +7 | Cancun, Mexico | CUN | 26,558 | 62.1 | % |
| 30 | +1 | San Salvador, El Salvador | SAL | 24,694 | 7.7 | % |
| 31 | +1 | Curitiba, Brazil | CWB | 24,417 | 8.0 | % |
| 32 | -7 | São Paulo, Brazil | CGH | 23,383 | -20.1 | % |
| 33 | same | Belém, Brazil | BEL | 19,460 | -7.7 | % |
| 34 | +3 | Buenos Aires, Argentina | AEP | 18,945 | 38.3 | % |
| 35 | same | Merida, Mexico | MID | 18,469 | 10.0 | % |
| 36 | +3 | Izquitos, Peru | IQT | 15,155 | 22.8 | % |
| 37 | +5 | Iquique, Chile | IQQ | 14,590 | 66.2 | % |
| 38 | same | Tijuana, Mexico | TIJ | 14,382 | 13.3 | % |
| 39 | -5 | Belo Horizonte, Brazil | CNF | 13,404 | -20.3 | % |
| 40 | +1 | Ciudad del Este, Paraguay | AGT | 12,301 | 30.3 | % |
| 41 | -1 | Vitoria, Brazil | VIX | 11,120 | 11.3 | % |
| 42 | +6 | San Andres, Colombia | ADZ | 8,361 | 22.6 | % |
| 43 | +1 | São Luis, Brazil | SLZ | 8,000 | 9.1 | % |
| 44 | +3 | Cuiaba, Brazil | CGB | 7,719 | 10.3 | % |
| 45 | -2 | Cartagena, Colombia | CTG | 7,072 | 1.0 | % |
| 46 | same | Natal, Brazil | NAT | 7,048 | -0.7 | % |
| 47 | — | Puerto Plata, Dom. Rep. | POP | 6,897 | -16.9 | % |
| 48 | -3 | Florianopolis, Brazil | FLN | 6,891 | -5.5 | % |
| 49 | — | San Pedro Sula, Honduras | SAP | 6,794 | 26.0 | % |
| 50 | — | Asuncion, Paraguay | ASU | 6,729 | 23.8 | % |
| Loaded and unloaded freight and mail in metric tonnes. | ||||
| Havana, Cuba (HAV) was not included due to insufficient data. | ||||
| Source: Airports Council International | ||||
